Our Theory

<body topmargin=0 leftmargin=0 marginheight=0 marginwidth=0> <table cellpadding=0 cellspacing=0 border=0><tr> <td valign="top" colspan=2 height=85 BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <FONT SIZE="5" COLOR="#000000" FACE="Arial" ><B>PROJEK KECEMERLANGAN BALIK PULAU</B></FONT><FONT SIZE="1" COLOR="#000000" FACE="Arial" ><B>     </B></FONT><B>|     </B><A HREF="index.htm" TARGET="_top" TITLE="PROJEK KECEMERLANGAN BALIK PULAU"><U><B>home</B></U></A></div> <div> <A HREF="id17.htm" TARGET="_top" TITLE="Assignment"><U>Assignment</U></A>   |   <A HREF="id18.htm" TARGET="_top" TITLE="News Headlines"><U>News Headlines</U></A>   |   <B>Our Theory </B>   |   <A HREF="id21.htm" TARGET="_top" TITLE="Leisure"><U>Leisure</U></A>   |   <A HREF="id20.htm" TARGET="_top" TITLE="Projects Diary"><U>Project's Diary</U></A>   |   <A HREF="id28.htm" TARGET="_top" TITLE="Download"><U>Download</U></A>   |   <A HREF="id24.htm" TARGET="_top" TITLE="FAQ"><U>FAQ</U></A>   |   <A HREF="id25.htm" TARGET="_top" TITLE="About Us"><U>About Us</U></A>   |   <A HREF="id26.htm" TARGET="_top" TITLE="Thanks To"><U>Thanks To</U></A></div> <div> </div> </td> </tr><tr> <td valign="top" width=180 BGCOLOR="#990033" TEXT="#080000"> <div> <B>OUR MAIN OBJECTIVES IN THIS PROJECT :</B></div> <bR> <div> <B><IMG BORDER="0" SRC="Symb075c00b700c8ccffff00.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Learn all about artificial sweetener .</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700c8ccffff00.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Show how aspartame was made .</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700c8ccffff00.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Prove aspartame is bad for health .</B></div> <div> <B><IMG BORDER="0" SRC="Symb075c00b700c8ccffff00.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Find the new way to minimize the bad effect .</B></div> <bR> <bR> </td> <td valign="top" height=395 BGCOLOR="#FFFFFF" TEXT="#080000"> <div> <I>Our Theory </I></div> <div> <B>Intro </B></div> <div> By :<FONT SIZE="1" COLOR="#0000FF" FACE="Arial" ><A HREF="mailto: sr8442@bristol.ac.uk." TARGET="_top" TITLE="mailto: sr8442@bristol.ac.uk."><U> Sarah Rogers</U></A></FONT></div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Aspartame is the artificial sweetener used in most diet drinks and other low calorie products . It is 200 times as sweet as table sugar ( sucrose ) but contains only 4 calories per gram .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Quotation taken from the Third Edition of Organic Chemistry - Structure and Function by K . Peter C Vollhardt and Neil E . Schore .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The acceptable daily intake is 40mg/kg .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The three main components in aspartame are : </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">aspartic acid </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">phenylalanine </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">methanol</div> <div> The structure of aspartame is as follows :</div> <div> <IMG SRC="1a4bb980.gif" border=0 width="187" height="152" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> *This diagram was copied from the homepage of Dr. R.J. Cox.</div> <bR> <bR> <div> <B>Synthesis ( </B><B>The Strecker Synthesis )</B></div> <div> By :<FONT SIZE="1" COLOR="#0000FF" FACE="Arial" ><A HREF="mailto: sr8442@bristol.ac.uk." TARGET="_top" TITLE="mailto: sr8442@bristol.ac.uk."><U> Sarah Rogers</U></A></FONT></div> <bR> <div> <IMG SRC="1a5b7860.gif" border=0 width="439" height="134" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> <div> *This diagram was copied from the home page of Dr. R. J. Cox.</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The product of the Strecker Synthesis is a racemic mixture of phenylalanine , which is one of the components of Aspartame .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The racemic mixture is composed of both L and D phenylalanine . Only L phenylalanine is used to make Aspartame . Therefore , the two forms must be separated . </div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">This can be done by reacting the racemic mixture with Ac<FONT SIZE="1" COLOR="#000000" FACE="Arial" >2</FONT>O and NaOH. The product of this reaction is then treated with Porcine Kidney Acylase and an organic extraction with H<FONT SIZE="1" COLOR="#000000" FACE="Arial" >3</FONT>O<FONT SIZE="1" COLOR="#000000" FACE="Arial" >+</FONT> is then carried out .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0"> The L form of phenylalanine will be found in the water layer and the D form will be found in the organic layer .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The acid group on phenylalanine must now be converted into an ester. This is done by treatment of L phenylalanine with MeOH and HCl .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Finally , Aspartame can be made by reaction of the compound created above with Aspartic acid . </div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The structure of aspartic acid can be found .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The amine group on Aspartic acid must be protected with Cbz and the acid group nearest the amine must be protected with benzyl as they are a reactive sites that we do not wish to react with the pheylalanine . </div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The other acid group must then be activated with BOP </div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">BOP is removed as phenlyalanine is added, but the protecting groups remain . Cbz is removed by a reaction of H<FONT SIZE="1" COLOR="#000000" FACE="Arial" >2</FONT>/PtO<FONT SIZE="1" COLOR="#000000" FACE="Arial" >2</FONT> with MeOH and CHCl<FONT SIZE="1" COLOR="#000000" FACE="Arial" >3</FONT> and benzyl is removed by reation of H<FONT SIZE="1" COLOR="#000000" FACE="Arial" >2</FONT>/Pd/C and MeOH and CHCl<FONT SIZE="1" COLOR="#000000" FACE="Arial" >3 </FONT>.</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0"> Aspartame has now been made .</div> <bR> <bR> <div> <B>Protecting And Activating Group</B></div> <div> By :<FONT SIZE="1" COLOR="#0000FF" FACE="Arial" ><A HREF="mailto: sr8442@bristol.ac.uk." TARGET="_top" TITLE="mailto: sr8442@bristol.ac.uk."><U> Sarah Rogers</U></A></FONT></div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">A protecting group is used when there are two or more reactive sites present in a molecule , but only one is required to react. </div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">The active sites that are not wished to react are protected with a protecting group . Typical protecting groups for amines are: </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Benzyl .</div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Cbz - Carbobenzyloxy .</div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">BOC - Butyloxy Carbonyl .</div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Fmoc - Fluorenylmethoxy Carbamate .</div> <bR> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Typical protecting groups for carboxylates are Methyl ester ,  t-Butyl ester  and Benzyl ester .</div> <div>              </div> <div> <IMG BORDER="0" SRC="Wing0a7300a800c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">An activating group is used to make a reactive site even more reactive. Typical activating groups for carboxylates are DCC with DMAP , EDCI with DMAP and BOP .</div> <bR> <bR> <div> <B>Toxicity Effects of Aspartame Use</B></div> <div> By : <FONT SIZE="1" COLOR="#0000FF" FACE="Arial" ><A HREF="mailto:ahkee_ahch@hotmail.com" TARGET="_top" TITLE="mailto:ahkee_ahch@hotmail.com"><U>Amar Faiz</U></A></FONT></div> <bR> <div> Selection of Health Effects from Short-term and/or Long-Term Use</div> <div> Note: It often takes at least sixty days without *any* aspartame or NutraSweet to see a significant improvement. Check all labels very carefully (including vitamins and pharmaceuticals). Look for the word "aspartame" on the label and avoid it. (Also, it is a good idea to avoid "acesulfame-k" or "sunette.") Finally, avoid getting nutrition information from junk food industry PR organizations such as IFIC or organizations that accept large sums of money from the junk and chemical food industry such as the American Dietetic Association. </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Seizures and Convulsions </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Dizziness </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Tremors </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Migraines and Severe Headaches (Trigger or Cause From Chronic Intake) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Memory Loss (common nutrasweet toxicity effects) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Slurring of Speech </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Confusion </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Numbness or Tingling of Extremities </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Chronic Fatigue </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Depression </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Insomnia </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Irritability </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Panic Attacks (common aspartame toxicity reaction) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Marked Personality Changes </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Phobias </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Rapid Heart Beat, Tachycardia (another frequent nutrasweet reaction) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Asthmatic Reactions </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Chest Pains </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Hypertension (High Blood Pressure) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Nausea or Vomitting </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Diarrhea </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Abdominal Pain </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Swallowing Pain </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Itching </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Hives (Urticaria) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Other Allergic-Like Reactions </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Blood Sugar Control Problems (Hypoglycemia or Hyperglycemia) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Menstrual Problems or Changes </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Impotency and Sexual Problems </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Craving for Food </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Weight Gain </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Hair Loss (Baldness) or Thinning of Hair </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Burning Urination & Other Urination Problems </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Excessive Thirst or Hunger </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Bloating, Edema (Fluid Retention) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Infection Susceptibility </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Joint Pains </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Brain Cancer (Pre-approval studies in animals) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Death </div> <bR> <div> Aspartame Disease Mimmicks Symptoms or Worsens the Following Diseases</div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Fibromyalgia </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Arthritis </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Multiple Sclerosis (MS) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Parkinson's Disease </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Lupus </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Multiple Chemical Sensitivities (MCS) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Diabetes and Diabetic Complications </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Epilepsy </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Alzheimer's Disease </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Birth Defects </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Chronic Fatigue Syndrome </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Lymphoma </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Lyme Disease </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Attention Deficit Disorder (ADD) </div> <div> <IMG BORDER="0" SRC="Symb075c00b700c800000000.gif" HEIGHT="13" WIDTH="24" ALIGN="bottom" HSPACE="0" VSPACE="0">Panic Disorder </div> <div> Depression and other Psychological Disorders </div> <bR> <bR> <div>  <embed src="HTMLobj-495/Eternal_Harvest.mid" autostart="true" loop="true" hidden="true">  </div> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <div>             </div> <div>               </div> <div>     </div> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> <bR> </td> </tr></table></body>